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GIDGET -- MOMMY'S GIRL

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Gidget is Amee's special girl.   I fostered Gidget in 2020-2021.   I went on vacation and asked my daughter to watch out dogs, but Amee watched Gidget.  Gidget never came back home with me.  She was home with Amee.
Gidget came into rescue with her brother, Rocky in December 2020.   She was 9 at the time,  She had white eyelashes which gave her a distinct look.  
Gidget welcomed Autumn to her home recently.  She knows what it is like to be the new one.  
Gidget also thinks she's the queen bee, so she lets them know she is in charge.  
Autumn is so glad that Gidget let her stay.  
Gidget had a bath the other day.  Her mom messaged me to see if I could hear her screaming--and I'm almost 100 miles away.  LOL   Gidget CAN SING!!
Gidget is now 13.  It's hard to believe.  As she had gotten older, she has decided that she enjoys fruit.  Her mom said mango is her favorite.  I love mango, too.   
Gidget may be a little older now, but she will always be her mommy's girl.  💜


 

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tabithaclem
4 days ago
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PIPER AND PADDINGTON—BIRTHDAY!

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Piper and Paddington came into rescue 6 years ago last month.  
Their owner was in the hospital and couldn’t take of them anymore.  Paddington looks at Piper as his father figure. 
They had all their medical completed.  My husband had never asked to keep any of the dogs I fostered.  But he asked if we could keep them. ❤️❤️ 
Paddington has grown long beautiful ears. He is a stunning red Peke.  
Piper has become my shadow.  Where I go, he goes.  I was told he was a Malti-Poo.  When I did a DNA test on him, he wasn’t a Malti-Poo.  He was a Shih Tzu/Maltese.  And he even has 2% Pekingese!  
Paddington is a big mush.  You can hold him on his back like a baby.  I can trim his nails and he doesn’t budge. 
They found the Pekingese pathway in the yard right after they came.  
Paddington has the nickname “Bad Pad.”  He has been known to be a pistol w male foster dogs.  😩
But how could I stay mad at this face.  Nope.  Can’t do it. 
When Cinnamon came into rescue, Paddington became her protector.  He has never fussed at her!  
Now they celebrated another birthday here.  Paddington turned 9 and Piper turned 10. 

Happy birthday Piper and Paddington. 🎂❤️🎂❤️
Let’s all celebrate! 🥳🎉




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tabithaclem
8 days ago
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Metamorphine, An Unwelcome Product

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Now this is one that I wouldn't have seen coming. In hospital settings it's common to use patient-controlled analgesia (PCA) pumps for management of severe pain. These infuse a solution containing morphine together with nonopioid analgesics directly into a patient's intravenous connection, and allow them to deal with their own experience of pain and their own tolerance for it. This system actually tends to result in lower analgesic doses than would otherwise be administered and improves the patient experience in general.

But a couple of years ago questions were raised about one commonly used mixture. There have naturally been IV solution stability studies of the main analgesics used (morphine, hydromorphone, esketamine, and metamizole), but it turned out that the morphine/metamizole combination was not as stable in solution (an effect first noted in doctoral work in 2009). Hydromorphone/esktamine mixtures were completely stable at 22C and at 37C, but while a morphine/metamizole mix held up at 22C, it showed significant ongoing loss of both components at 37 degrees. 

This turns out to be due to the formation of a Mannich condensation adduct between metamizole and morphine (shown at right) which has been given the name "metamorphine". Metamizole itself can decompose to provide the formaldehyde needed. This new paper characterizes it thoroughly and looks into its pharmacology, and it turns out to still be a nanomolar ligand at the mu-opioid receptor. That's 8- to 10-fold weaker than morphine, but still very much in the pharmacological activity range (remember, morphine is the standard by which opioid agonists are judged!) This was unexpected, since that's a pretty large group to hang off the morphine backbone. But there are some changes on the metamizole - metamorphine seems to have lost all of metamizole's anti-inflammatory activity.

As long as PCA pumps are kept at room temperature, this shouldn't be a problem. But if they are too close to the patient's body, left on or near warm equipment, or exposed to sunlight, you could see some problems. Never assume without checking that your chemicals are going to do what they're supposed to or remain what they say they are on the label - particularly in solution!

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tabithaclem
8 days ago
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LOUIE AND LADY

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Louie came into rescue in 2011. Lady came to us in 2021.
Katie was Louie’s sister.  They were adopted together.  When she crossed the Rainbow Bridge, Louie was the only dog.  
When Lady came into rescue in 2021, I knew she would be a wonderful sister for Louie.  She was older but still had a lot of life left. 
They are great friends and are 
close to each other most of the time.  
Look at those sweet faces. I just want to kiss them both. 🥰

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tabithaclem
12 days ago
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HAPPY BIRTHDAY REN

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Ren just had a birthday. 
She came into rescue in late 2019.  Her sisters, Jinjie and Mei Mei came with her.  
Ren turned 14! 🎂🎂
Ren is amazed by Noelle, her foster sister.   Noelle has so much energy. 
Ren has a simpler way to play.  Just roll on your back and hold the toy. That takes much less energy. 
Have enough beds Ren?   You can do whatever you want!  It’s your birthday! 🎂🎂
 

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tabithaclem
15 days ago
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Otter sits on a capybara

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Otter sits on a capybara

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tabithaclem
27 days ago
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